Ultra Rapid Detoxification (UROD)
Jul 28, · When undergoing ultra-rapid detox, an opiate-addicted patient is put under general anesthesia. Once unconscious, a drug called naltrexone is flushed through the body via IV infusion. Naltrexone, an opioid receptor antagonist, purges opiates from the body and quickly causes the patient to enter withdrawal. In the ultra rapid detoxification (UROD) procedure, opiate detoxification is induced by the use of a bolus injection of very high doses of an opiate antagonist (naloxone) under general anesthesia or heavy sedation followed by a slow infusion of low-dose naloxone.
Ultra-Rapid Detoxification is a technique that was pioneered in the s to help people detoxify from opiates. Because older detoxification techniques were painful and usually unsuccessful, URD was developed.
URD involves putting patients under whta anesthesia and giving them Naltrexone to flush all of the opiates raid the brain receptors. Patients usually feel absolutely terrible after the procedure and there are some risks involved.
There are a number of centers around the world who still perform URD and in a supervised setting with experienced personnel and it seems to be a reasonable procedure where the risks rapif outweighed by the whatt. We Can Help Give us a call today to get started on the road to recovery. If you would rather have our office contact you at a later date, please click on the link below to schedule a time for us to call you back.
The Coleman Institute performed over URD procedures in a hospital and had no major complications. However because of the risks involved, the patients discomfort level and what is blue grass music high cost, we developed a new technique that would be just as successful and yet avoid the problems of URD. We have now performed thousands of Accelerated Detoxifications since and find the technique is vastly superior to our experience with URD.
Our Accelerated Detoxification procedure stabilizes the patients for days before the opiates are flushed off the brain receptors.
We avoid general anesthesia, which is dangerous and what happens if sea levels rise side effects. Any patients who have had a URD and detoz tried our newer Accelerated Detoxification technique have reported that the newer technique is greatly superior. Ultr Accelerated Detox Technique is equally as successful as URD but it is safer, easier on the patient, and is more affordable.
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Why We No Longer Do Ultra-Rapid Detoxification
What is Ultra Rapid Detoxification (URD)? Ultra-Rapid Detoxification is a technique that was pioneered in the s to help people detoxify from opiates. Because older detoxification techniques were painful and usually unsuccessful, URD was developed. Oct 25, · Ultra-rapid detox: The patient is sedated with a general anesthesia. Once the anesthesia has taken effect, doctors will administer an opioid blocker. The opioid blocker forces the body to begin detox. In theory, once a patient wakes up from sedation, the majority of the uncomfortable symptoms have already passed. Mar 24, · Ultra Rapid Detoxification method is one of the modern methods of detox followed in many drug rehab centers. This procedure is specially designed for those addicted to opioids. By following this procedure, one can easily and quickly get off his/her opioid addiction physically/5().
Aetna considers ultra rapid detoxification UROD experimental and investigational as a clinical detoxification treatment and for all other indications because its effectiveness has not been established.
Detoxification, although important, is only the first step in long-term relapse prevention treatment of opiate addiction. Proven detoxification procedures presently involve a gradual withdrawal followed by medication and long-term psychosocial support in producing long-term abstinence from illicit opioid use.
In the ultra rapid detoxification UROD procedure, opiate detoxification is induced by the use of a bolus injection of very high doses of an opiate antagonist naloxone under general anesthesia or heavy sedation followed by a slow infusion of low-dose naloxone. The 4-hour procedure is carried out in an intensive care unit and the patient requires 1 to 2 days of hospitalization for a full treatment protocol. Proponents of the procedure claim that complete accelerated detoxification is attained, the patient experiences no withdrawal symptoms, physical dependency is eliminated, and the psychological craving for drugs is greatly reduced.
However, experts prominent in the field of opiate addiction in reported their concerns about UROD stating that detoxification is not a cure for opiate addiction and that medication without psychosocial support has little impact on opiate addiction.
There is no scientifically-based evidence in the medical literature to substantiate that UROD is safe and effective as a clinical detoxification treatment. There is a reported risk of serious adverse events, including death with the use of anesthetics, making the risk:benefit ratio of this detoxification procedure unacceptable. Besides direct causality associated with inadvertent anesthetic over-dose, there is also the risk of indirect causality related to possible aspiration and choking from emesis that may occur when an anesthetized or heavily sedated individual is detoxified while asleep.
To date, only 1 double-blind study and few research reports have systematically documented the nature of the UROD procedure and its safety and efficacy for both immediate detoxification and longer term relapse prevention.
No double-blind studies indicate that ultra-short detoxification procedures are more successful in decreasing relapse to opiates than longer duration treatments. The CTAF assessment concluded: "Existing published studies of rapid detoxification and ultra rapid detoxification have raised the prospect of new approaches to opioid detoxification. However, methodological limitations limit the generalizability of the studies, and thus these techniques, to widespread clinical application.
Lack of randomization and blinding, sample size variations, different clinical profiles of studied patients, and diverse pharmacologic treatment used and clinical settings, preclude comparisons between studies and the drawing of any firm conclusions regarding the efficacy and safety of these procedures. The post-detoxification relapse rate for these techniques appears to be quite variable. The most suitable patients for these procedures must still be defined.
Both rapid and ultra rapid opioid detoxification must undergo further scientific evaluation in randomized, controlled trials to determine whether their clinical effectiveness and safety outweigh their risks. Further research is also warranted to evaluate longer-term outcomes and compare these methods with other treatments for opioid addiction such as methadone maintenance supervised methadone taper, naltrexone maintenance, counseling-supported abstinence, and toxicological surveillance. A structured evidence review by Gowing et al reached the following conclusions about UROD: "Heavy sedation compared to light sedation does not confer additional benefits in terms of less severe withdrawal or increased rates of commencement on naltrexone maintenance treatment.
Given that the adverse events are potentially life-threatening, the value of antagonist-induced withdrawal under heavy sedation or anaesthesia is not supported. The high cost of anaesthesia-based approaches, both in monetary terms and use of scarce intensive care resources, suggest that this form of treatment should not be pursued.
An UpToDate review on "Opioid detoxification during treatment for addiction" Weaver and Hopper, stated that "Serious complications have been reported with anesthesia-assisted rapid detoxification, and a randomized trial did not find it to be superior to buprenorphine-assisted rapid detoxification, or clonidine-assisted detoxification.
In this study, the three detoxification strategies resulted in no differences in rates of completion of inpatient detoxification or completion of the treatment program at 12 weeks; the overall dropout rate was 82 percent. There were three serious adverse events, all occurring in the anesthesia group. A systematic review of five randomized trials found that the potential serious harms and costs of heavy sedation or anesthesia, and lack of benefit from this procedure, do not support this method of detoxification.
We believe that ultrarapid opiate detoxification is not a medically sound therapy and should be avoided". Guidelines from the National Institute for Health and Clinical Excellence stated that "Ultra-rapid and rapid detoxification using precipitated withdrawal should not be routinely offered. This is because of the complex adjunctive medication and the high level of nursing and medical supervision required".
The guidelines also stated that "Ultra-rapid detoxification under general anaesthesia or heavy sedation where the airway needs to be supported must not be offered.
This is because of the risk of serious adverse events, including death". Blum et al noted that over the past 20 years, the prescription of high dose opiate therapy has continued to accelerate in an attempt to treat patients with chronic pain. This presents a substantial challenge when patients on high dose opiate therapy require surgery, as opiate pain relief is a cornerstone of post-operative pain management. These patients have exceptionally challenging pain to control. This is likely due to down-regulation of existing opiate receptors and the reluctance of clinicians to increase doses of opiates to exceptionally high levels to facilitate pain relief.
These researchers hypothesized that using the method of UROD, it would be possible to rapidly increase the number of opiate receptors and return patients to a more naive state, which would be susceptible to exogenous opiate administration.
Validation of this hypothesis is supported by 2 mechanisms, the first of which were reports of patients that underwent UROD for opiate addiction that subsequently suffer respiratory arrests when beginning to rapidly abuse opiates shortly after treatment. Additionally there were data demonstrating the tapering of opiate therapy prior to elective surgery resulted in better pain control. The authors concluded that they hypothesized that patients on chronic high dose opiates could obtain substantially better pain relief if they underwent UROD prior to surgery.
This technique could be administered shortly before surgery and may dramatically improve the patients' recoveries. This hypothesis need to be tested in well-designed studies. Qiu et al examined alterations of resting brain function in codeine-containing cough syrups CCS dependent individuals before and after UROD under general anesthesia combined with naltrexone treatment NMT. The amplitude of low frequency fluctuations ALFF and seed-based functional connectivity FC were used to characterize resting-state cerebral function.
The authors concluded that they provided the first report describing how regional and integral synchronous neural activity occurred after UROD and short-term NMT, accompanied by decreased withdrawal syndrome severity. The included guideline recommended against the use of UROD, due to high risk for adverse events. Review History. Clinical Policy Bulletin Notes. Links to various non-Aetna sites are provided for your convenience only. Aetna Inc. Print Share.
Number: Policy Aetna considers ultra rapid detoxification UROD experimental and investigational as a clinical detoxification treatment and for all other indications because its effectiveness has not been established. Background Detoxification, although important, is only the first step in long-term relapse prevention treatment of opiate addiction.
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